Prabhu is the host of a television show called Real Or Reel. There, he interviews two women: Kanmani Ganguly and Khatija Begum. Both are very much in love with Ranjankudi Anbarasu Murugesa Boopathy Ohondhiran aka Rambo, who also loves them back.

In the flashback, Rambo hails from a village that believed his family was cursed. Whoever married in his family would die. Rambo's father decides to break the myth and marries a local teacher named Minah Kaif, while his brothers and sister remained unmarried. Rambo's father is overjoyed after the birth of his son, whom he names Ranjankudi Anbarasu Murugesa Boopathy Ohondhiran (Rambo). Unfortunately, while announcing his son's birth, he accidentally slips from a tower and dies. His wife Minah suffers a stroke shortly after and is paralyzed. Rambo's uncles and aunts, and the whole village believe that the birth of Rambo has brought bad luck that his father tried so hard to fight. Rambo grows up believing that he emanates bad luck wherever he goes. When his mother suffers a seizure in his presence, he runs away from the village for good, believing that his proximity to his mother makes her ill. He goes to the city and lives far away from his family, but continues to have contact with them.

Years later, Rambo takes up two jobs to earn a living. During the daytime, he works as a cab driver. At night, he works as a bouncer at a pub. He meets Khatija at the bar every evening and the two develop a friendship. Rambo notices Khatija's violent boyfriend: Mohammed Mobi, who slaps her one night, so he intervenes and fights Mobi. Khatija breaks up with Mobi and starts hanging out with Rambo every evening. On the other hand, Kanmani works as a saleswoman and raises her younger sister Minmini and differently-abled brother Bhargav. She attempts to find a husband who would allow her to live with her siblings even after marriage, but in vain. Rambo works as her cab driver during the day and the two develop a mutual attraction. Days go by and the two women fall for Rambo and propose to him on the same day. Though Rambo is surprised that two fabulous women have fallen for him, he is quick to realize that only their love has turned his bad luck around for good, so he accepts both of their proposals.

Not knowing how to proceed with his double love life, he gets help from Prabhu, a reality show host, who makes Rambo concoct a story that he has a memory disorder that makes him forget events that happened during the day and night alternately. The staging is a disaster when Rambo reveals that he has memory of both the women and is equally in love with both, it is up to them to sacrifice their love for the other person. Kanmani and Khatija refuse to do so and stand by their decision to marry Rambo. The three move in together, and though both women dislike each other at first, after the unexpected death of Khatija's father, they strike a friendship. After a point, the two find out that Rambo staged the show and kick him out of the house. Rambo's friend asks them to travel to the village one last time to see Rambo's mother who is seriously ill. Rambo decides not to go back as he fears his presence could worsen her condition. He is forced to go and his mother miraculously recovers, now the villagers believe Rambo's presence gives out good luck. They beg both Khatija and Kanmani to marry Rambo so the family's curse could be broken and all his uncles and aunt can be married. They finally agree and host a wedding ceremony for not only Rambo, but also his entire family.

Shortly after the rest of the family is married, Khatija and Kanmani walk out of the wedding, each sacrificing their love so the other person can marry Rambo. A year later, the three still meet with Rambo saying that their relationship was enough to break the curse. After the two women leave, Rambo shocks his neighbour and tells that Katrina Kaif has started chatting with him as his new girlfriend. Rambo throws his phone and leaves, leaving an unaware Katrina waiting for him online.