The film opens with the killing of a police officer by a cocaine-dealer lord Bhai and his henchmen. Kokila struggles to find a job to take care of her parents and sister. She stumbles on the cocaine smuggling business of Mohan. When her mother is diagnosed with lung cancer, Kokila is forced to work for Mohan. Her cunningness earns her a name in the business. The new inspector Guru is a no-nonsense cop and cracks down on drug dealers. Kokila is almost caught a couple of times but manages to evade the authorities. She convinces Mohan to kill two of his henchmen suspected of leaking information and then decides to quit the business. Mohan seemingly agrees but tries to kill her, however an enraged Kokila brutally murders Mohan and his men and tries to flee with her family but is caught by Bobi, who had recruited her initially.

He demands that she deliver a one last consignment of 100 kilos to Alphonse. Kokila is forced to accept and enlists the help of her family. Shekhar and Lakshman Kumar join them unaware of their smuggling. She delivers the load, but it is revealed that she switched most of it for salt. She then tricks Bobi to double-cross Bhai and then frames him for swindling Bhai. She has him killed and continues the shipment run. On the way, she is caught by the police, who were Alphonse's men in disguise. She manages to avoid getting tortured and kills off her captors with the help of her family. Guru tracks her down and arrests her. Kokila makes a deal with him to nab Bhai and bring the whole drug business down. The plan works out, Bhai is shot dead by Guru, and Kokila and her family escape punishment and Guru helps the family by giving some financial support. In the end, the family starts a legitimate business of Kolam powder, calling it 'Kolamaavu Kokila'.