During the reign of the Mughal emperor Akbar, young Meera, influenced by the story of Andal and Krishna, is deeply in love with Krishna, so much so that she considers him to be her husband after she garlands him on an auspicious day as advised by her mother. As Meera matures into a young woman, her devotion to Krishna grows.

Against her wishes, Meera is married to Rana, the king of Mewar. But even after marriage, her love for Krishna remains unchanged. She follows her own ideals and way of living which are unacceptable to Rana and his family, especially his brother Vikram and sister Udha. Meera asks Rana to construct a temple for Krishna in Chittor, the capital of Mewar. Out of love for her, Rana agrees. An overjoyed Meera remains in the temple most of the time, singing in praise of Krishna along with other devotees, and avoids staying at the palace.

On Vijayadashami, Rana expects Meera to be with him at the royal assembly when other kings come to offer their respects. But en route to the assembly, Meera hears Krishna's flute playing, returns to the temple and remains there. Rana becomes angry upon realising that Meera has returned to the temple again, ignoring her duties as a wife. To kill Meera, Vikram has Udha give her a poisoned drink. Meera is saved by Krishna and the poison does not kill her; instead, Krishna's idol at the Vithoba Temple turns blue, and the sanctum's double-doors at Dwarakadheesh Temple close spontaneously, and remain closed.

At Delhi, Akbar learns of Meera's singing and her devotion to Krishna. He sends her a pearl necklace as a gift, which Meera puts on Krishna's idol. Rana becomes angry when he learns of these developments and her disinterest in fulfilling her duties as a wife and queen; he orders the demolition of the temple using cannons so that she will leave. Vikram goes to the temple and orders Meera and the other devotees to come out before the demolition begins. However, Meera refuses, remains in the temple and continues her bhajans.

Meanwhile, Rana learns from Udha of Vikram's failed attempt to kill Meera. Shocked when he realises Meera's real identity (she is one with Krishna), he rushes to meet her in the temple, which is about to be demolished. When a cannon is fired, Rana stops it and is injured. When Meera hears Krishna calling her, she admits to Rana that she has failed in her duties as a wife. She explains that her heart is with Krishna and seeks Rana's permission to leave palace life and fulfill her desire to visit Krishna's temple at Dwarka; Rana realises her devotion and agrees. Once Meera leaves, Mewar suffers from a drought and the subjects plead with Rana to bring Meera back, so Rana goes in search of her.

Meera first goes to Brindavanam and meets the sage, who originally predicted her devotion. Together, they leave for Dwarka, Krishna's birthplace. On reaching the temple, she starts singing in praise of Krishna. Rana, who has followed her, also reaches the temple. The temple's doors, which were closed till then, open. Krishna appears and invites Meera inside. Meera runs towards Krishna and falls dead while her soul merges with him. Rana comes rushing in and finds Meera's corpse. Her devotion to Krishna is finally rewarded, and Meera is united with him.