Nachiappan is a wealthy and successful Indian American restaurateur based in Los Angeles. He has two sons – Viswanathan "Visu" and Ramamoorthy "Ramu" – who are identical twins. They both are medical students and spend their evenings helping out their father alongside the restaurant's chief cook, Juno. One evening, when Visu & Ramu go to the airport to do their lunch supply, Visu sees an Indian Tamil family from Chennai – Madhumitha "Madhu", her younger brother Madhesh, and their grandmother Krishnaveny – having some problems with the immigration authorities. Visu pitches in to help and learns that they just flew in from India so that Krishnaveny can undergo a surgery to remove her brain tumour. After many confusions, the trio meets with Ramu also. The twins arrange for the three to reach their host.
Krishnaveny is admitted in the hospital where Visu works as a resident doctor and the surgery is performed. Visu soon realises that Krishnaveny is paralysed as she was operated on the wrong side of her brain due to a mix-up with another patient. He appeals aggressively to the doctors and has the error corrected by another surgery, then spearheads an angry fight for compensation. The hospital compensates US$2 million to avoid a court case. Due to these actions, Madhu soon falls in love with Visu.
Krishnaveny soon realises that Madhu and Visu are in love and extends the family's stay in the US. However, Nachiappan objects to the romance as he wants his sons to marry identical twin girls. In a flashback, it is shown that Nachiappan had an identical twin brother Pechiappan, who lives in Karaikudi and is a simpleton. They both married for love in their youth, but Pechiappan's wife Sundarambal tortured and abused Nachiappan's pregnant wife Meiyaththa so badly that the latter died after giving birth to Visu and Ramu. Nachiappan eventually left the house along with Visu and Ramu to prevent Pechiappan and Sundarambal from separating over Meiyaththa's death.
Krishnaveny decides to solve the problem by lying to Nachiappan that Madhu does have an identical twin named Vaishnavi, who was raised separately in an orthodox Brahmin household. The reason for their separation is claimed that "having twins would bring bad luck on their family". Nachiappan falls for the lie and leaves for India along with Visu, Ramu, Juno, Krishnaveny, Madhu and Madhesh in order to "meet" Vaishnavi and fix the marriages of Visu and Ramu with Madhu and Vaishnavi respectively. Krishnaveny has Madhu pose as Vaishnavi, who contrary to Madhu, is very demure and traditional in nature. Ramu immediately falls in love with Vaishnavi, unaware that she is Madhu. Meanwhile, Pechiappan, whose marriage with Sundarambal has worsened due to the latter's inability to have children, attempts suicide. Nachiappan rescues him and hatches a plan to unite both the families through Visu's and Ramu's marriage plan. Nachiappan impersonates Pechiappan and leaves for Karaikudi, where with his business sense and practical nature, he rescues Pechiappan's failing restaurant business and eventually reforms Sundarambal as well. Pechiappan takes Nachiappan's place and stays with Visu and Ramu.
Eventually, Madhu, realising that Ramu is madly in love with her alter-ego, decides to stop acting as Vaishnavi as she feels she is hurting Ramu's as well as Visu's feelings through her act. Visu too finds out in parallel that Vaishnavi does not exist. Enraged, Visu and his family immediately leave Madhu's house, but Ramu tells him that Madhu had lied due to her love for him and convinces him to reconcile with her. Ramu further manages to convince his father, unaware that he is his uncle Pechiappan, to get Visu and Madhu married. When Nachiappan realises the truth and finds out that Visu and Madhu are getting married, he immediately rushes to Chennai with Sundarambal and stops the wedding. At this point, it is revealed that both Nachiappan and Pechiappan had impersonated each other in order to reunite both the families. Sundarambal manages to convince Nachiappan to get Visu and Madhu married since Madhu, by posing as Vaishnavi, had done the same thing that Nachiappan and Pechiappan did. Visu and Madhu get married. Later, at their reception, Madhesh entertains the couple and guests with computer-generated special effects.
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