The plot begins in a remote village in Tamil Nadu named Pannaipuram. The director Venkat Prabhu wished to the god for the movie to launch. Samikannu (Premgi), the son of a karagattam artist named Karagattakkarar (Shanmugasundaram); Vinayakam (Jai), the son of a military man named Manickam (Chandrasekhar); and Ramarajan (Vaibhav), the son of the local bigwig Nattamai (Vijayakumar) and the village casanova are three rebellious youths who repeatedly attempt to flee their village and see the outside world but are usually caught and punished by the conservative elders. After being punished harshly, they attempt one last escape and succeed. The trio runs away to the town of Madurai, hoping to stay with Vinay's friend Azhagar.
On arriving at Azhagar's place, they find him marrying an American named Angelina Jolie. Azhagar tells them that he had met her in Goa months ago and they fell in love. He tells the trio that they will spend their honeymoon in London and after that he will be moving over to London as his father-in-law has secured him a nice job there. The three friends are inspired to travel to Goa, meet a foreign woman there, and marry her to escape from their miserable life in India. The next day, on finding out that Samikannu had mistakenly brought along a pile of sacred golden jewels from their village temple and thus the 3 can never return, they pack their bags and head to Goa.
At Goa, they meet a fellow Tamil named Jack (Aravind Akash), who provides food and shelter and introduces them to the party culture of Goa. Jack also hosts a party which Ramarajan meets Suhashini (Sneha) . Vinay falls in love with Roshini (Piaa Bajpai), a club singer, while Sam attempts to woo an American named Jessica Alba (Melanie Marie), whom he had seen earlier at the wedding in Madurai. The three friends are given a makeover by Jack and Roshini, and they begin a new lifestyle in Goa.
At this point, enters hotelier Daniel (Sampath Raj), who is Jack's lover and a transgender man. Danny is attracted by Sam's innocence and begins making affectionate advances toward him; Sam is oblivious. This invokes the jealousy of Jack, who hires ninja-themed henchmen to beat up Sam. In an awkwardly heroic scene, Sam nullifies their attack.
Ram's life takes a twist after he comes across Suhasini Fernando (Sneha). They begin dating, and Ram learns that she is a wealthy entrepreneur who owns a luxury cruise ship named Casino Royale. The two eventually get married, and Ram gifts her the golden jewel from his village, which she locks in a secret room aboard her yacht. Soon, the trouble starts. Ram learns that Suhasini is slightly neurotic: a fact revealed to him by her former husband Shakthi (Prasanna). The marriage takes a bitter turn, and Ram turns to his friends for help. Together, they plan a covert mission and successfully retrieve the jewel.
Vinay and Sam are successful in their romance. The three boys eventually return to their native village, along with Roshini, Jessica, Danny, and Jack. There, a surprise awaits Ram, in the form of Nayantara. The epilogue takes place in Goa, showing Suhasini falling in love with Madhan Kumar (Silambarasan Rajendar). As they hug, Madhan's nose begins to bleed, indicating that Suhasini has become a victim of Manmadhan.
The film parodies various themes prevalent in Tamil cinema, as well as many popular Tamil songs. Director Venkat Prabhu makes several cameos throughout the film.
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